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Figure 2: Echocardiographic monitoring of tumor size: (a) Tumor size charted based on ellipse area calculation (A = πab in cm2). The right ventricular and left ventricular apical tumors are measured from the apical 4-chamber view. The right ventricular outflow tract and left ventricular outflow tract tumors are measured from anterior apical or subcoastal views. The first time-point for right ventricular and left ventricular is from the fetal echocardiogram. Parasternal long axis view showing right and left apical rhabdomyomas (b; where the smaller left ventricular outflow tract tumor is seen as well) and the apical view (c) at end diastole on Day of life 7, before treatment with Everolimus. Echo images after 2 weeks of treatment with Everolimus show reduction in tumor size from the parasternal long (d) and apical (e) views

Figure 2: Echocardiographic monitoring of tumor size: (a) Tumor size charted based on ellipse area calculation (<i>A </i>= <i>π</i><i>ab in cm</i><sup>2</sup><i>).</i> The right ventricular and left ventricular apical tumors are measured from the apical 4-chamber view. The right ventricular outflow tract and left ventricular outflow tract tumors are measured from anterior apical or subcoastal views. The first time-point for right ventricular and left ventricular is from the fetal echocardiogram. Parasternal long axis view showing right and left apical rhabdomyomas (b; where the smaller left ventricular outflow tract tumor is seen as well) and the apical view (c) at end diastole on Day of life 7, before treatment with Everolimus. Echo images after 2 weeks of treatment with Everolimus show reduction in tumor size from the parasternal long (d) and apical (e) views