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Figure 1: (a) Anterior view of the thorax of a normal 22-week fetus, the heart located in the thoracic mediastinum. (b) Transversal section stained with hematoxylin and eosin from a human fetus at 20 weeks of development. Note the orientation of the heart in relation to the remaining structures. (c) Four chamber view at 25 weeks of gestation. This heart has been opened to show the extent of the pectinate muscles in the morphologically RA. The off-setting of the hinges of the leaflets of the mitral and tricuspid valves is evident. Ao: Aorta, IVS: Interventricular septum, E: Esophagus, LA: Left atrium, LAA: Left atrial appendage, LV: Left ventricle, LSPV: Left superior pulmonary vein, MV: Mitral valve, OF: Oval fossa, PT: Pulmonary trunk, RA: Right atrium, RAA: Right atrial appendage, RIPV: Right inferior pulmonary vein, RV: Right ventricle, SCV: Superior caval vein, TC: Terminal crest, TV: Tricuspid valve

Figure 1: (a) Anterior view of the thorax of a normal 22-week fetus, the heart located in the thoracic mediastinum. (b) Transversal section stained with hematoxylin and eosin from a human fetus at 20 weeks of development. Note the orientation of the heart in relation to the remaining structures. (c) Four chamber view at 25 weeks of gestation. This heart has been opened to show the extent of the pectinate muscles in the morphologically RA. The off-setting of the hinges of the leaflets of the mitral and tricuspid valves is evident. Ao: Aorta, IVS: Interventricular septum, E: Esophagus, LA: Left atrium, LAA: Left atrial appendage, LV: Left ventricle, LSPV: Left superior pulmonary vein, MV: Mitral valve, OF: Oval fossa, PT: Pulmonary trunk, RA: Right atrium, RAA: Right atrial appendage, RIPV: Right inferior pulmonary vein, RV: Right ventricle, SCV: Superior caval vein, TC: Terminal crest, TV: Tricuspid valve