Year : 2021  |  Volume : 14  |  Issue : 3  |  Page : 269--277

Outcome of COVID-19-positive children with heart disease and grown-ups with congenital heart disease: A multicentric study from India


Sakshi Sachdeva1, Sivasubramanian Ramakrishnan1, Mrigank Choubey1, Nageswara Rao Koneti2, Kalaivani Mani3, Shweta Bakhru2, Saurabh Kumar Gupta1, Debasree Gangopadhyay4, Soumya Kasturi5, Jayashree Mishra6, Hemant Kumar Nayak7, Kothandam Sivakumar8, Prashant Bobhate9, Neeraj Awasthy10, Debasis Das11, Manisha Chakrabarti12, Chinnaswamy Sivaprakasam Muthukumaran13, Rajan Saileela14, Bhargavi Dhulipudi2, Shiv Kumar Chaudhary15, Mahimarangaiah Jayranganath5, Anita Saxena1, Krishna Subramony Iyer16, Raman Krishna Kumar17, Shyam S Kothari1, Snehal Kulkarni9, Suresh G Rao18, For the PCSI-COVID-19 study group19 
1 Department of Cardiology, All India Institute of Medical Sciences, New Delhi, India
2 Department of Pediatric Cardiology, Rainbow Children's Heart Institute, Hyderabad, Telangana, India
3 Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India
4 Department of Pediatric Cardiology, Narayana Hrudalaya Rabindranath Tagore International Institute of Cardiac Sciences, Kolkata, West Bengal, India
5 Department of Pediatric Cardiology, Sri Jayadeva institute of Cardiovascular Sciences and Research, Bengaluru, Karnataka, India
6 Department of Pediatric Cardiology, Bai Jerbai Wadia Hospital for Children, Mumbai, Maharashtra, India
7 Department of Pediatric Cardiology, Mission Hospital, Durgapur, West Bengal, India
8 Department of Pediatric Cardiology, Institute of Cardiovascular Diseases, Madras Medical Mission, Chennai, Tamil Nadu, India
9 Department of Pediatric Cardiology, Kokilaben Dhirubhai Ambani Hospital, Mumbai, Maharashtra, India
10 Department of Pediatric Cardiology, Max Super Speciality Hospital, New Delhi, India
11 Department of Cardiac Surgery, Narayana Superspeciality Hospital, Kolkata, West Bengal, India
12 Department of Pediatric Cardiology, Apollo Hospital, New Delhi, India
13 Department of Pediatric Cardiology, Apollo Hospital, Chennai, Tamil Nadu, India
14 Department of Pediatric Cardiology, MIOT Centre for Children's Cardiac Care, MIOT Hospital, Chennai, Tamil Nadu, India
15 Department of Cardio-Thoracic and Vascular Surgery, All India Institute of Medical Sciences, New Delhi, India
16 Department of Pediatric and Congenital Heart Surgery, Fortis Escorts Heart Institute, New Delhi, India
17 Department of Pediatric Cardiology, Amrita Institute of Medical Sciences, Kochi, Kerala, India
18 Children's Heart Center, Kokilaben Dhirubhai Ambani Hospital, Mumbai, Maharashtra, India

Correspondence Address:
Dr. Sivasubramanian Ramakrishnan
Department of Cardiology, All India Institute of Medical Sciences, New Delhi
India

Background : Outcome data of children with heart disease who acquired COVID-19 infection are limited. Aims : We sought to analyze outcome data and identify risk factors associated with mortality in children with heart disease and grown-ups with congenital heart disease (GUCH) who had a laboratory-confirmed COVID-19 infection. Settings and Design : This is a retrospective, multicentric, observational study. Materials and Methods : The study included children with heart disease and GUCH population, who presented with either symptomatic or asymptomatic COVID-19 infection to any of the participating centers. COVID-19-negative patients admitted to these centers constituted the control group. Results : From 24 pediatric cardiac centers across India, we included 94 patients with a median age of 12.5 (interquartile range 3–96) months and 49 (52.1%) patients were males. Majority (83 patients, 88.3%) were children. One-third of the patients (n = 31, 33.0%) had acyanotic congenital heart disease, and 41.5% (n = 39) were cyanotic, with > 80% of the patients being unoperated. Only 30 (31.9%) patients were symptomatic for COVID-19 infection, while the rest were incidentally detected positive on screening. A total of 13 patients died (case fatality rate: 13.8%). The in-hospital mortality rate among hospitalized patients was significantly higher among COVID-19-positive cases (13 of 48; 27.1%) as compared to COVID-negative admissions (9.2%) during the study period (P < 0.001). On multivariate analysis, the independent predictors of mortality among COVID-19-positive cases were severity of illness at admission (odds ratio [OR]: 535.7, 95% confidence interval [CI]: 6.9–41,605, P = 0.005) and lower socioeconomic class (OR: 29.5, 95% CI: 1.1–814.7, P = 0.046). Conclusions : Children with heart disease are at a higher risk of death when they acquire COVID-19 infection. Systematic preventive measures and management strategies are needed for improving the outcomes.


How to cite this article:
Sachdeva S, Ramakrishnan S, Choubey M, Koneti NR, Mani K, Bakhru S, Gupta SK, Gangopadhyay D, Kasturi S, Mishra J, Nayak HK, Sivakumar K, Bobhate P, Awasthy N, Das D, Chakrabarti M, Muthukumaran CS, Saileela R, Dhulipudi B, Chaudhary SK, Jayranganath M, Saxena A, Iyer KS, Kumar RK, Kothari SS, Kulkarni S, Rao SG, FC. Outcome of COVID-19-positive children with heart disease and grown-ups with congenital heart disease: A multicentric study from India.Ann Pediatr Card 2021;14:269-277


How to cite this URL:
Sachdeva S, Ramakrishnan S, Choubey M, Koneti NR, Mani K, Bakhru S, Gupta SK, Gangopadhyay D, Kasturi S, Mishra J, Nayak HK, Sivakumar K, Bobhate P, Awasthy N, Das D, Chakrabarti M, Muthukumaran CS, Saileela R, Dhulipudi B, Chaudhary SK, Jayranganath M, Saxena A, Iyer KS, Kumar RK, Kothari SS, Kulkarni S, Rao SG, FC. Outcome of COVID-19-positive children with heart disease and grown-ups with congenital heart disease: A multicentric study from India. Ann Pediatr Card [serial online] 2021 [cited 2021 Nov 27 ];14:269-277
Available from: https://www.annalspc.com/article.asp?issn=0974-2069;year=2021;volume=14;issue=3;spage=269;epage=277;aulast=Sachdeva;type=0