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Table of Contents   
REVIEW ARTICLE  
Year : 2021  |  Volume : 14  |  Issue : 4  |  Page : 507-515
Necrotizing enterocolitis and congenital heart disease


1 UCL Medical School, University College London, London, United Kingdom
2 Faculty of Medicine, Imperial College London, London, United Kingdom
3 School of Medicine, University of Liverpool, Liverpool, United Kingdom
4 Department of Paediatric Intensive care, Alder Hey Children's Hospital, Liverpool, United Kingdom
5 Department of Cardiothoracic Surgery, Liverpool Heart and Chest Hospital; Department of Congenital Cardiac Surgery, Alder Hey Children Hospital, Liverpool, United Kingdom

Click here for correspondence address and email

Date of Submission11-Feb-2021
Date of Acceptance26-May-2021
Date of Web Publication25-Mar-2022
 

   Abstract 


Necrotizing enterocolitis (NEC) remains a prominent surgical emergency among infant population, associated with a significant mortality, as well as various subsequent morbidities. Congenital heart disease (CHD) has an increased associated incidence with NEC in infant population. Recent research has provided insight into the pathophysiology of NEC in patients with CHD and how this differs from those without CHD. The deviation from normal circulatory physiology has a suggested association in the pathophysiology of NEC in CHD, which may have implications for the risk factors of NEC in infants with CHD, the effect on outcomes of NEC, and whether alternative approaches to management may need to be considered in comparison to classical NEC. This review aims to highlight studies that provide insight and awareness into the relationship between NEC and CHD, in order that clinicians may direct themselves more clearly toward optimal management for infants in this category.

Keywords: Bowel surgery, interventions, outcomes, pediatrics

How to cite this article:
Kashif H, Abuelgasim E, Hussain N, Luyt J, Harky A. Necrotizing enterocolitis and congenital heart disease. Ann Pediatr Card 2021;14:507-15

How to cite this URL:
Kashif H, Abuelgasim E, Hussain N, Luyt J, Harky A. Necrotizing enterocolitis and congenital heart disease. Ann Pediatr Card [serial online] 2021 [cited 2022 May 22];14:507-15. Available from: https://www.annalspc.com/text.asp?2021/14/4/507/340947





   Introduction Top


Necrotizing enterocolitis (NEC) is a commonly encountered gastrointestinal emergency and a leading cause of morbidity and mortality in the neonatal population.[1],[2] The typical characteristics of NEC include breaching of the gut mucosal barrier by pathogenic enteric bacteria, which results in intestinal inflammation, hypoxia, ischemia, and necrosis.[3],[4] In the last few decades, although mortality rates in premature infants have decreased significantly due to advancements in the management of respiratory distress syndrome and other aspects of neonatal care, the incidence of NEC has generally remained the same as a result of greater ability to distinguish NEC from similarly presenting conditions balanced against the increased risk of NEC in infants born at younger gestational ages.[5],[6] This disease entity typically afflicts 5%–7% of preterm infants, particularly those infants who are of very low birth weight (VLBW <1500 g).[7] However, in full-term neonates, NEC has an association with certain congenital anomalies such as congenital heart disease (CHD), with an incidence ranging between 1.6% and 6% in full-term infants with NEC and CHD.[4],[8],[9],[10],[11],[12] Prevalence and mortality of NEC in CHD have varied significantly among different studies.[9],[13],[14],[15],[16],[17],[18],[19] Infants with complex CHD have a notably higher risk of developing NEC.[11],[20] Numerous studies have been performed aimed at identifying unique risk factors contributing to NEC in patients with CHD as well as the underlying pathophysiology so that provision of care may be anticipated and optimized.


   Pathophysiology Top


The pathophysiology of NEC has not been completely elucidated. Proposed theories include a multifactorial disease process, resulting in intraluminal bacteria disrupting and invading intestinal epithelial cells.[21],[22] Subsequently, adherence of leukocytes and platelets to the endothelium prevents microvascular blood flow in the small intestine, resulting in tissue injury.[23]

Several studies suggest alternative pathophysiology in infants who develop NEC with coexisting CHD. It has been theorized that CHD infants have low diastolic pressures and consequently lower bowel perfusion pressures, in addition to low systemic oxygenated blood.[2],[18],[24] Ultimately, the bowel is hypoperfused and ischemic.[18],[24] Different types of CHDs can contribute to NEC development. Patent ductus arteriosus and significant left-to-right shunting are thought to lead to pulmonary hyperperfusion and systemic hypoperfusion – resulting in superior mesenteric diastolic blood flow being restricted.[25],[26] Cyanotic CHD can predispose the infant to a generalized state of hypoxia, which may facilitate development of NEC.[27] Similarly, ductal-dependent (DD) CHD (e.g., coarctation of the aorta and atrioventricular canal defect) can lower diastolic gut perfusion pressures and restrict oxygenated blood flow in the systemic circulation, directly leading to gastrointestinal circulatory insufficiency and ischemia.[28] Infants with atrioventricular canal experience pulmonary over circulation and accompanying atrioventricular valve regurgitation, leading to reduced systemic output.[29] A summary of the proposed pathophysiology is summarized in [Figure 1].
Figure 1: Pathophysiology of necrotizing enterocolitis in patients with congenital heart disease

Click here to view


However, during interventions involving arch reconstruction, the use of deep hypothermia aims to protect the bowels from ischemia.[30] The infant may still be predisposed to NEC postoperatively due to reperfusion injury and the increase of proinflammatory cytokines.[30] It was observed that in infants who developed NEC, the occurrence of tissue damage in the colon was more frequent in infants with CHD as compared to those without CHD. This corroborates the theory of alternative pathophysiology of NEC in patients with CHD as the colon is at a comparatively increased risk of hypoxic or ischemic injury.[2] It has been observed that infants who developed NEC with CHD had significantly lower APGAR scores at 1 and 5 min after birth and required a higher level of respiratory support after delivery, further supporting the role of ischemia as a major contributor of NEC in infants with CHD.[31]


   Risk Factors of Necrotizing Enterocolitis in Infants with Congenital Heart Disease Top


A retrospective case–control study found that neonates with hypoplastic left heart syndrome (HLHS) are at the highest risk of developing NEC when compared with other CHDs.[9] Children with truncus arteriosus and aortopulmonary window also carry a significantly increased risk.[9] DD lesions have been shown to have increased rates of developing NEC as compared to non-DD lesions.[19],[28] However, in premature or VLBW infants, the presence of atrioventricular canal defect is associated with the highest risk of NEC development.[29]

Certain studies identify prostaglandin (PGE) use as another possible risk factor for NEC in infants with CHD, attributable to side effects such as apnea and hypotensive episodes, particularly at infusion rates greater than 0.05 μg/kg/min.[9] However, in a recent study, no association was observed between use of PGE and the risk of developing NEC in infants with CHD.[15] In another study, the risk of NEC in infants with DD lesions on PGE therapy was observed to be 0.3%,[28] thus suggesting that PGE usage is a nonmajor risk factor. Further studies on larger cohorts will be required to decisively conclude the magnitude of PGE as a risk factor compared to others discussed.

Previously, feeding practices in infants with CHD have been analyzed with no clear significance of the risk between enteral feeding or parenteral nutrition and the subsequent development of NEC.[17],[19] However, recent studies shed further light upon the risk of enteral feeding and its role in the development of NEC. No significant difference was found in either enteral or parenteral feeds, therefore supporting the use of the enteral route in CHD.[28],[32] One observational study found that initiating enteral feeding in the preoperative period leads to low risk (0.9%) of NEC in infants.[33] Further studies will be required, with larger cohorts, to conclude the relationship of enteral feeding as a risk factor for NEC in infants with CHD. However, consideration can be given to the benefits of initiating early enteral feeding postoperatively in infants, including reduced length of stay, decreased time till full enteral nutrition, and reduced time till first stool.[34]

Studies have shown that NEC may be more common in the postoperative period,[17],[33] following cardiac surgery. With regard to specific procedures, NEC rates were higher in infants who had received a systemic to pulmonary shunt procedure compared to other procedures.[12] In addition, one study showed a higher incidence of NEC associated with red blood cell transfusion.[35] The risk factors described so far relate to infants with CHD who develop NEC. Other risk factors such as prematurity or gestational age are generally considered significant and important risk factors for NEC in neonates born without CHD.[36] These risk factors have also been shown in studies including neonates with CHD, indicating that prematurity or gestational age has a significant association in the development of NEC in this group.[9],[37] A summary of possible risk factors discussed is shown in [Figure 2].
Figure 2: Risk factors for necrotizing enterocolitis in patients with congenital heart disease

Click here to view



   Diagnostic Approach Top


Clinically, NEC can present in many different ways among infants, which can make it more difficult for clinicians to diagnose the condition at the earliest and least severe stage of pathogenesis. NEC may present anywhere on the clinical spectrum, ranging from slow and insidious to rapid and progressive.[38],[39] The diagnosis of NEC is based on variable clinicoradiologic signs and extent of involvement. Staging criteria are utilized to assign disease severity and determine treatment. Bell's classification has traditionally been the standard for severity assessment in NEC [Table 1].
Table 1: Modified Bell's staging criteria for necrotizing enterocolitis

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Most commonly, both small and large bowels are affected; the next most frequent location of disease involvement is the small bowel alone. In infants with congenital heart disease and NEC, the colon is most commonly affected.[36] Interestingly, a retrospective study showed seven patients with CHD (0.9%) developed NEC, of which all had nontypical radiologic findings, resulting in delayed diagnosis with five patients having developed bowel perforation.[40] This suggests that clinicians may need to have a higher suspicion of NEC occurrence in infants with CHD.


   Treatment Top


Necrotizing enterocolitis management

Management of NEC in infants with CHD, where the underlying pathophysiology itself consists of distinct features, may need to be approached with an alternative perspective. Current management for NEC in infants with CHD is generally derived from guidance on classic NEC, with little unique consideration given to patients with CHD.[2],[41] Management of NEC involves supportive care, empirical antibiotic therapy, parenteral nutrition, and bowel rest with gastric decompression initiated as soon as NEC is suspected.[42] In a retrospective study, it was observed that no patient among the entire cohort (n = 251) developed NEC preoperatively when the protocol of enteral feeding in neonates with DD lesions included continuous trophic feeds if nil per os since birth or trophic transpyloric feeds if the neonate was not stable.[8] This same study additionally suggested a provisional antibiotic guideline to address the variation of regimens found in infants with CHD.[8] Briefly, they suggest ampicillin, gentamicin ± metronidazole for suspected NEC; ampicillin if hemodynamically stable or vancomycin and piperacillin-tazobactam if unstable with confirmed NEC; and vancomycin and piperacillin-tazobactam in advanced NEC.[8] Surgical therapy is indicated according to clinical signs or investigations suggesting bowel perforation, such as pneumoperitoneum on an abdominal radiograph, or in the case of failure of medical therapy.[42]

Timing of surgical intervention

Current literature suggests that severity, of NEC in infants with CHD, is generally less when compared to classical NEC.[17] Infants with CHD have a reduced likelihood of developing clinically important morbidities such as perforation of the bowel, resulting in a need for stomas or development of short bowel syndrome, or sepsis, in comparison to classical NEC.[43] A recent study also showed that a smaller percentage of infants with CHD who developed NEC underwent surgical intervention as compared to infants without CHD, suggesting consistency with findings of reduced severity of NEC in infants with CHD in the literature.[2]

However, after excluding suspected NEC cases (Stage I), Cheng et al.[27] found that earlier surgery in proven NEC cases without perforation, i.e., Stages II and IIIA, resulted in higher survival than those managed medically (n = ¾, 75% vs. n = 4/9, 44%).[27] In patients with CHD and NEC, where surgery was clearly indicated, surgical intervention was successful in saving 33% of these patients (n = 3/6 vs. n = 0/2).[27] This suggests that surgical management did not present a greater risk of mortality and resulted in a higher survival in comparison to medical treatment, although not statistically significant.[27] Therefore, suggesting the consideration of possible surgery earlier before it is clinically indicated with evidence of bowel perforation.

A more recent study found that macroscopic intestinal necrosis was present with greater frequency intraoperatively in infants with CHD and NEC in comparison to infants without CHD.[44] This should prompt the earlier consideration of surgical intervention for NEC in patients with CHD. It is difficult to evaluate current literature for queries such as whether surgical intervention should occur earlier, delayed after medical management fails, or reserved until clinical signs of perforation are apparent. Further studies are required into this aspect of management for NEC in infants with CHD to provide clearer and consistent conclusions.

Cardiac surgical interventions

In neonates with DD lesions, important components of the management during an acute situation comprise initiation of a PGE infusion at a rate of 5–10 ng/kg/min and consideration for definitive repair through either surgical therapy or transcatheter therapy as diastolic pressures remain low in this form of CHD.[45],[46] Having discussed the possible nature of PGE infusion as a risk factor for NEC, along with other potentially detrimental side effects, the infusion rates are set to the minimally effective dose.[9],[45]

Stenting of the ductus arteriosus may be considered early in DD systemic lesions followed with bidirectional cavopulmonary connection for definitive repair.[46] However, in cases involving transposition of great arteries, consideration can be made for a balloon atrial septostomy.[45],[46] For single ventricle heart defects such as HLHS, one retrospective study compared the risk of gastrointestinal complications such as NEC between first-stage palliation procedures such as the Norwood modified Blalock-Taussig shunt, Norwood right ventricle to pulmonary artery conduit (Sano repair), and a hybrid procedure, finding that the gastrointestinal complications were minimal in infants who underwent a Sano repair compared to the other procedures.[47] However, the incidence of NEC was not significantly distinguishable between the procedures.[47] Further research will be required to elucidate the association of NEC following cardiac surgical interventions.

Initial surgical intervention – Necrotizing enterocolitis surgery or cardiac surgery?

In a retrospective study spanning from 2008 to 2011, records of neonates who developed severe NEC postoperatively after surgical correction of a CHD were reviewed.[41] In three patients, managing NEC before surgical correction of the CHD significantly relapsed in the postoperative period.[40]

A case–control study looked at NEC in four CHD infants who were undergoing surgical cardiac procedures.[48] Although this study was comprised of a very small cohort, the authors reported that NEC may have occurred due to mesenteric ischemia which correlated with a perfusion state that was lower in the perioperative period.[48] It is therefore logical that the initial surgical intervention should tackle the CHD to possibly prevent or reverse NEC occurrence, given that there are no contraindications.[27]

There does not appear to be extensive research available in this niche area, and thus, more studies in this cohort of patients are required to ascertain and clarify the risk–benefit profile.


   Outcomes Top


Mortality

Surprisingly, Pickard et al.[43] showed that patients with NEC who also suffered from a CHD had a significant survival advantage.[43] However, there was notable heterogeneity between the study groups (NEC with CHD vs. NEC without CHD), which may have influenced the study outcome. First, Pickard et al.[43] included neonates with suspected NEC at an unbalanced ratio of 29% in neonates with CHD versus 21% in neonates without CHD.[43] Moreover, there were fewer patients with advanced Grade III NEC in CHD group (22%) than in patients without CHD (44%), resulting in better outcomes for patients with NEC and CHD.[43]

However, a recent retrospective study by Kessler et al.[49] that only included patients with confirmed NEC (Bell Stage ≥II) and a comparable rate of severe disease (Bell Stage III) in both groups, found that patients with CHD and confirmed NEC had higher rates of overall mortality.[49] This is in keeping with other studies which found that neonates with both NEC and CHD had worse outcomes in terms of mortality than patients with a single disease.[29],5[50],[51],[52]

When stratified by type of CHD, Lau et al.[19] found that although patients with DD lesions and complex patients with RACHS-1 >2 were more likely to develop NEC after cardiac surgery, mortality is similar regardless of DD.[19] Cheng et al.[27] found that cyanotic patients had higher mortality than the acyanotic group (n = 5/13, 71% vs. n = 12/17, 39% respectively).[27] [Table 2] summarizes the studies to date comparing mortality rates in NEC patients with and without CHD.
Table 2: Summary of mortality rates in necrotizing enterocolitis patients with and without congenital heart disease

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Complications

A recent meta-analysis of 58 studies, including 4260 patients, found that gastrointestinal sequelae in neonates surviving surgery for NEC are a frequent problem, which should not be underestimated when assessing disease outcome.[9] Strictures (24%), interstitial fluid (13%), recurrence of NEC (8%), and adhesion ileus (6%) were the most commonly reported complications.[53] After controlling for birth weight and gestational age, Pickard et al.[43] found that neonates with CHD-NEC had decreased risk of perforation, requiring an operation, strictures, need for a stoma, sepsis, and short bowel syndrome compared with neonates without CHD.[43]

Kessler et al.[49] found that surviving CHD-NEC neonates do not have more gastrointestinal complications than patients without CHD (overall 13%).[49] Similarly, Bubberman et al.[2] found that the complication rates were comparable between both groups.[2] When stratified by type of CHD, Cheng et al.[27] found that gut perforation was more common in acyanotic CHD neonates compared to those with cyanotic CHD (n = 6/13, 46% vs. n = 5/17, 29%).[27] McElhinney et al.[9] reported that the mean hospital stay was significantly longer in CHD patients that developed NEC than those who did not develop NEC (36 ± 22 days vs. 19 ± 14 days).[9]


   Conclusion Top


In infants with CHD, ischemia and hypoxic damage are the major risk factors within the pathophysiology of NEC. Furthermore, the major risk factors for NEC in the context of CHD may be distinct with specific forms of CHD, such as DD lesions and atrioventricular canal in VLBW infants, carrying a significantly higher risk of NEC. Literature suggests the logical approach that the initial surgical interventions address the cardiac defect to tackle the driving pathophysiology of NEC. PGE use and enteral feeding studies do not provide any conclusions collectively, and further research will be required using larger cohorts.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
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Correspondence Address:
Mr. Amer Harky
Department of Cardiothoracic Surgery, Liverpool Heart and Chest Hospital, Thomas Drive, L14 3PE
United Kingdom
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/apc.apc_30_21

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    Figures

  [Figure 1], [Figure 2]
 
 
    Tables

  [Table 1], [Table 2]



 

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