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Osama Abd Rab Elrasol Tolba, Mohamed Ramadan El-Shanshory, Mohamed Abd Elaziz El-Gamasy, Walid Ahmed El-Shehaby
Department of Pediatric, Faculty of Medicine, Tanta University, Tanta, Gharbia, Egypt
Correspondence Address:
Mohamed Abd Elaziz El-Gamasy
Department of Pediatric, Tanta University Hospital, El Giesh Street, Tanta, Gharbia
Egypt
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/apc.APC_140_16
Background: Cardiac dysfunction is a risk factor for death in patients with sickle cell disease (SCD).
Aim of the Work: Aim of the work is to evaluate the right ventricular systolic and diastolic functions by tissue Doppler and speckling tracking imaging in children with SCD.
Subjects and Methods: Thirty children with SCD and thirty controls were subjected to clinical, laboratory evaluations, and echocardiographic study using GE Vivid 7 (GE Medical System, Horten, Norway with a 3.5-MHz multifrequency transducer) including; Two-dimensional and tissue Doppler echocardiographic study (lateral tricuspid valve annulus peak E' velocity, lateral tricuspid valve annulus peak A' velocity, E'/A' ratio, isovolumetric relaxation time, lateral tricuspid valve annulus S' and septal S' waves and peak longitudinal systolic strain [PLSS] and time to PLSS) were done in six right ventricular segments.
Results: There was a significant decrease in right ventricular systolic and diastolic function in patients group when compared to controls.
Conclusions: Children with SCD have impaired right ventricular systolic and diastolic functions when compared to healthy children with early evaluation of the systolic dysfunction by speckle tracking imaging technique.
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